Dermamelan
A professional depigmentation protocol for persistent hormonal pigmentation and melasma
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What it is
A professional depigmentation protocol for persistent pigmentation
Dermamelan is a professional depigmentation protocol developed by mesoestetic that combines an intensive in-clinic treatment mask with a prescribed home maintenance programme. It is designed specifically for persistent pigmentation concerns — particularly melasma, chloasma and hormonally influenced pigmentation — where surface-level approaches alone may be insufficient.
The protocol works through a dual mechanism: addressing existing surface pigmentation while also targeting the enzyme pathways involved in melanin production at a cellular level. This dual approach aims to address both the visible pigmentation and the underlying pigment-producing activity, which may support a more sustained treatment response compared to surface treatments alone.
Dermamelan is a medical-grade protocol requiring practitioner assessment and prescription. It is not appropriate for all skin types or pigmentation presentations — a thorough consultation is required before treatment proceeds. As with all pigmentation treatments, individual responses vary and realistic expectations are discussed at consultation.
What it addresses
Pigmentation concerns
This treatment may be considered for the following concerns. Suitability is confirmed at consultation.
- Melasma and chloasma
- Hormonal pigmentation including pregnancy-related pigmentation
- Post-inflammatory hyperpigmentation (PIH)
- Persistent pigmentation that has not responded adequately to topical management alone
- Uneven skin tone associated with pigmentation irregularity
- Sun-induced pigmentation in appropriate candidates
The protocol
How Dermamelan works
Dermamelan is a two-phase protocol — an intensive in-clinic phase followed by a prescribed home maintenance programme. Both phases are essential to the treatment.
What to expect
The treatment experience
Your first appointment begins with a thorough skin and pigmentation assessment. Your practitioner will assess the type, distribution and depth of your pigmentation, your skin type and your overall health history. This assessment determines whether Dermamelan is appropriate for your situation and informs the treatment approach. Pricing is confirmed at this appointment.
On the day of your in-clinic treatment, the Dermamelan mask is applied to cleansed skin and left on for a prescribed period. The mask may produce a warming or tingling sensation during application. Following the prescribed wear time, the mask is removed and immediate aftercare is applied. You will leave the clinic with specific instructions for the following days.
In the days following treatment, the skin will typically appear red, feel tight and begin to peel. This peeling phase is part of the expected skin renewal process and typically spans approximately 7 to 10 days, though individual timelines vary. Planning social and professional commitments around this recovery period is advisable.
Recovery + Maintenance
What to expect following treatment
The recovery period following the in-clinic Dermamelan treatment typically involves redness, tightness and peeling over approximately 7 to 10 days. The extent of peeling varies by individual skin type and the prescribed mask duration. Specific aftercare instructions are provided at your appointment and should be followed carefully during this period.
Following recovery, changes in the skin's pigmentation appearance develop progressively. Individual responses vary and the timeline differs between clients. Ongoing use of the prescribed maintenance cream and daily broad-spectrum SPF 50+ is essential — without these, the treatment response may be significantly reduced over time.
Melasma and hormonal pigmentation are ongoing conditions. Dermamelan addresses the pigmentation present at the time of treatment and works to regulate melanin activity going forward — however the underlying tendency toward pigmentation does not disappear. Ongoing sun protection, maintenance skincare and periodic reassessment are part of managing these conditions long term.
As with all treatments, risks are associated with Dermamelan. Your practitioner will discuss all relevant risks and aftercare requirements in full at your consultation before any treatment proceeds.
Frequently Asked Questions
Common questions
Start with a Consultation
Dermamelan requires a thorough skin and pigmentation assessment before treatment proceeds. All new clients begin with a consultation to confirm suitability and discuss a realistic plan.